Tackling the growing incidence and prevalence of obesity urgently requires uncovering new
molecular pathways with therapeutic potential. The brain, and in particular the …

The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized,
while the precise molecular and cellular mechanisms involved are the focus of intense …

Obesity is a complex disorder, and the number of people affected is growing every day. In
recent years, research has confirmed the hypothesis that food addiction is a determining …

The endocannabinoid system (ECS) is a lipid signaling system involved in numerous
physiological processes, such as endocrine homeostasis, appetite control, energy balance …

Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance,
and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on …

Background and Purpose The enzyme α/β‐hydrolase domain containing 6 (ABHD6), a new
member of the endocannabinoid system, is a promising therapeutic target against neuronal …

Hypothalamic regulation of feeding and energy expenditure is a fundamental and
evolutionarily conserved neurophysiological process critical for survival. Dysregulation of …

Objective The hypothalamic paraventricular nucleus (PVN) is a key target of the
melanocortin system, which orchestrates behavioral and metabolic responses depending on …

Interscapular brown adipose tissue (BAT) has the capability to take up glucose from the
circulation. Despite the important role of BAT in the control of glucose homeostasis, the …

Obesity is a chronic and debilitating disorder that originates from alterations in energy-
sensing brain circuits controlling body weight gain and food intake. The dysregulated …