Bioactive polysaccharides from seaweeds

F Hentati, L Tounsi, D Djomdi, G Pierre, C Delattre… - Molecules, 2020 - mdpi.com
Bioactive compounds with diverse chemical structures play a significant role in disease
prevention and maintenance of physiological functions. Due to the increase in industrial …

Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions

A Abeysinghe, R Deshapriya, C Udawatte - Life sciences, 2020 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder and is identified as the most
common cause for dementia. Despite huge global economic burden and the impact on the …

The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives

L Wanka, K Iqbal, PR Schreiner - Chemical reviews, 2013 - ACS Publications
A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: In vitro and in vivo characterization

E Sánchez-López, M Ettcheto, MA Egea… - Journal of …, 2018 - Springer
Background Memantine, drug approved for moderate to severe Alzheimer's disease, has not
shown to be fully effective. In order to solve this issue, polylactic-co-glycolic (PLGA) …

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

TJ Revett, GB Baker, J Jhamandas, S Kar - Journal of Psychiatry and …, 2013 - jpn.ca
Alzheimer disease is the most prevalent form of dementia globally and is characterized
premortem by a gradual memory loss and deterioration of higher cognitive functions and …

Mechanism of action of memantine

JW Johnson, SE Kotermanski - Current opinion in pharmacology, 2006 - Elsevier
Memantine is a clinically useful drug in many neurological disorders, including Alzheimer's
disease. The principal mechanism of action of memantine is believed to be the blockade of …

Pharmaceuticals that contain polycyclic hydrocarbon scaffolds

TP Stockdale, CM Williams - Chemical Society Reviews, 2015 - pubs.rsc.org
Numerous variations on structural motifs exist within pharmaceutical compounds that have
entered the clinic. These variations have amounted over many decades based on years of …

TGF-β receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis

S Ivens, D Kaufer, LP Flores, I Bechmann, D Zumsteg… - Brain, 2007 - academic.oup.com
It has long been recognized that insults to the cerebral cortex, such as trauma, ischaemia or
infections, may result in the development of epilepsy, one of the most common neurological …

Neurological diseases and pain

D Borsook - Brain, 2012 - academic.oup.com
Chronic pain is a frequent component of many neurological disorders, affecting 20–40% of
patients for many primary neurological diseases. These diseases result from a wide range of …

Mitochondrial calcium cycling in neuronal function and neurodegeneration

GC Walters, YM Usachev - Frontiers in cell and developmental …, 2023 - frontiersin.org
Mitochondria are essential for proper cellular function through their critical roles in ATP
synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic …