The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
[HTML][HTML] Resting-state network dysfunction in Alzheimer's disease: a systematic review and meta-analysis
Introduction We performed a systematic review and meta-analysis of the Alzheimer's
disease (AD) literature to examine consistency of functional connectivity alterations in AD …
disease (AD) literature to examine consistency of functional connectivity alterations in AD …
Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
It is not known exactly where amyloid-β (Aβ) fibrils begin to accumulate in individuals with
Alzheimer's disease (AD). Recently, we showed that abnormal levels of Aβ42 in …
Alzheimer's disease (AD). Recently, we showed that abnormal levels of Aβ42 in …
The “rights” of precision drug development for Alzheimer's disease
There is a high rate of failure in Alzheimer's disease (AD) drug development with 99% of
trials showing no drug-placebo difference. This low rate of success delays new treatments …
trials showing no drug-placebo difference. This low rate of success delays new treatments …
[HTML][HTML] Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?
Biomarkers in whichever modality are tremendously important in diagnosing of disease,
tracking disease progression and clinical trials. This applies in particular for disorders with a …
tracking disease progression and clinical trials. This applies in particular for disorders with a …
Identifying and mapping connectivity patterns of brain network hubs in Alzheimer's disease
Alzheimer's disease (AD) is associated not only with regional gray matter damages, but also
with abnormalities in functional integration between brain regions. Here, we employed …
with abnormalities in functional integration between brain regions. Here, we employed …
Systematic review of different neuroimaging correlates in mild cognitive impairment and Alzheimer's disease
P Talwar, S Kushwaha, M Chaturvedi… - Clinical neuroradiology, 2021 - Springer
Alzheimer's disease (AD) is a heterogeneous progressive neurocognitive disorder. Although
different neuroimaging modalities have been used for the identification of early diagnostic …
different neuroimaging modalities have been used for the identification of early diagnostic …
Aging effects on whole-brain functional connectivity in adults free of cognitive and psychiatric disorders
LK Ferreira, ACB Regina, N Kovacevic… - Cerebral …, 2016 - academic.oup.com
Aging is associated with decreased resting-state functional connectivity (RSFC) within the
default mode network (DMN), but most functional imaging studies have restricted the …
default mode network (DMN), but most functional imaging studies have restricted the …
Regional brain hypometabolism is unrelated to regional amyloid plaque burden
Abstract See Sorg and Grothe (doi: 10.1093/brain/awv302) for a scientific commentary on
this article. In its original form, the amyloid cascade hypothesis of Alzheimer's disease holds …
this article. In its original form, the amyloid cascade hypothesis of Alzheimer's disease holds …
Resting-state connectivity of the left frontal cortex to the default mode and dorsal attention network supports reserve in mild cognitive impairment
N Franzmeier, J Göttler, T Grimmer… - Frontiers in aging …, 2017 - frontiersin.org
Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the
extent of neuropathology, eg, in Alzheimer's disease. A putative functional neural substrate …
extent of neuropathology, eg, in Alzheimer's disease. A putative functional neural substrate …