Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …

Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …

Mesenchymal stem cells (MSCs) can be isolated from almost all tissues and effectively
expanded in vitro. Although their true in situ properties and biological functions remain to be …

Large multicenter clinical trials have led to two recently approved drugs for patients with
idiopathic pulmonary fibrosis (IPF); yet, both of these therapies only slow disease …

In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, capital city of Hubei
province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per …

The Wnt–β-catenin and PI3K-AKT-FOXO3a pathways have a central role in cancer. AKT
phosporylates FOXO3a, relocating it from the cell nucleus to the cytoplasm, an effect that is …

Background Mesenchymal stromal cells (MSCs) demonstrate considerable promise in
preclinical acute respiratory distress syndrome models. We wished to determine the efficacy …

Introduction Idiopathic pulmonary fibrosis is a progressive diffuse parenchymal lung disorder
of unknown etiology. Mesenchymal stem cell (MSC)-based therapy is a novel approach with …

Despite its disadvantages, the bleomycin animal model remains the best available
experimental tool for studying disease pathogenesis and testing of novel pharmaceutical …

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling system
regulates a variety of biological processes, including embryogenesis, angiogenesis, wound …