Transporters and drug-drug interactions: important determinants of drug disposition and effects
Uptake and efflux transporters determine plasma and tissue concentrations of a broad
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …
Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: Beyond pharmacological inhibition
KM Hanssen, M Haber, JI Fletcher - Drug Resistance Updates, 2021 - Elsevier
Resistance to chemotherapy remains one of the most significant obstacles to successful
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …
Multidrug resistance: Physiological principles and nanomedical solutions
S Kunjachan, B Rychlik, G Storm, F Kiessling… - Advanced drug delivery …, 2013 - Elsevier
Multidrug resistance (MDR) is a pathophysiological phenomenon employed by cancer cells
which limits the prolonged and effective use of chemotherapeutic agents. MDR is primarily …
which limits the prolonged and effective use of chemotherapeutic agents. MDR is primarily …
Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy
D Keppler - Drug transporters, 2011 - Springer
The nine multidrug resistance proteins (MRPs) represent the major part of the 12 members
of the MRP/CFTR subfamily belonging to the 48 human ATP-binding cassette (ABC) …
of the MRP/CFTR subfamily belonging to the 48 human ATP-binding cassette (ABC) …
[HTML][HTML] Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance
The membrane proteins mediating the ATP-dependent transport of lipophilic substances
conjugated to glutathione, glucuronate, or sulfate have been identified as members of the …
conjugated to glutathione, glucuronate, or sulfate have been identified as members of the …
Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development
Human contains 49 ATP-binding cassette (ABC) transporter genes and the multidrug
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …
The role of ABC transporters in ovarian cancer progression and chemoresistance
Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …
course of the disease. A well-established cause of chemoresistance involves the family of …
[HTML][HTML] Structural, mechanistic and clinical aspects of MRP1
The cDNA encoding ATP-binding cassette (ABC) multidrug resistance protein MRP1 was
originally cloned from a drug-selected lung cancer cell line resistant to multiple natural …
originally cloned from a drug-selected lung cancer cell line resistant to multiple natural …
Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters
The 190 kDa multidrug resistance protein 1 (MRP1/ABCC1) is a founding member of a
subfamily of the ATP binding cassette (ABC) superfamily of transport proteins and was …
subfamily of the ATP binding cassette (ABC) superfamily of transport proteins and was …
Cellular uptake of dietary flavonoid quercetin 4′-β-glucoside by sodium-dependent glucose transporter SGLT1
RA Walgren, JT Lin, RKH Kinne, T Walle - Journal of Pharmacology and …, 2000 - ASPET
Although it has been suggested that the intestinal glucose transporter may actively absorb
dietary flavonoid glucosides, there is a lack of direct evidence for their transport by this …
dietary flavonoid glucosides, there is a lack of direct evidence for their transport by this …