Mathematical modeling of the glucose–insulin feedback system is necessary to the
understanding of the homeostatic control, to analyze experimental data, to identify and …

In β cells, stimulation by metabolic, hormonal, neuronal, and pharmacological factors is
coupled to secretion of insulin through different intracellular signaling pathways. Our …

Coordinated pulses of electrical activity and insulin secretion are a hallmark of the islet of
Langerhans. These coordinated behaviors are lost when β cells are dissociated, which also …

Impairment of insulin secretion from the β-cells of the pancreatic islets of Langerhans is
central to the development of type 2 diabetes mellitus and has therefore been the subject of …

The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review
applies an external bioenergetic critique to the central processes of glucose-stimulated …

Insulin is released from pancreatic islets in a biphasic and pulsatile manner in response to
elevated glucose levels. This highly dynamic insulin release can be studied in vitro with islet …

The individual study of C a 2+ and IP 3 dynamics respectively in a β-cell has yielded limited
information about the cell functions. But the systems biology approaches for such studies …

Aims/hypothesis We assessed the heterogeneity of insulin secretion from human isolated
beta cells and its regulation by cell-to-cell contacts. Methods Insulin secretion from single …

Islets of Langerhans are multicellular microorgans located in the pancreas that play a central
role in whole-body energy homeostasis. Through secretion of insulin and other hormones …

Pancreatic beta cells secrete insulin in response to stimulation with glucose and other
nutrients, and impaired insulin secretion plays a central role in development of diabetes …