Mitochondrial melatonin: beneficial effects in protecting against heart failure

RJ Reiter, R Sharma, LGA Chuffa, F Simko… - Life, 2024 - mdpi.com
Cardiovascular disease is the cause of physical infirmity and thousands of deaths annually.
Typically, during heart failure, cardiomyocyte mitochondria falter in terms of energy …

METTL3 silencing inhibits ferroptosis to suppress ovarian fibrosis in PCOS by upregulating m6A modification of GPX4

C Shen, Y Jiang, J Lin, Q Guo, D Fang - Journal of Molecular Histology, 2024 - Springer
Abstract Methyltransferase-like 3 (METTL3) is extensively reported to be involved in organ
fibrosis. Ovarian fibrosis is a main characteristic of polycystic ovary syndrome (PCOS) …

METTL3 silencing suppresses cardiac fibrosis via m6A modification of SMOC2

Y He, X Pan, Z Tao, Z Chen, S Ling - 2024 - researchsquare.com
Cardiac fibrosis leads to decreased cardiac compliance, impaired systolic and diastolic
function, resulting in heart failure. M6A methylation plays a role in fibrosis development …