Pyridine-based ring systems are one of the most extensively used heterocycles in the field of
drug design, primarily due to their profound effect on pharmacological activity, which has led …

The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

Phosphodiesterases (PDEs) are a class of enzymes that hydrolyze cyclic adenosine
monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) which is involved in …

A hybrid pharmacophore approach was adopted to design and synthesize new series of
isatin–pyridine hybrids. All the newly prepared hybrids (5a–o, 8 and 11a–d) were in vitro …

In our endeavor towards the development of effective anticancer agents, a novel series of
pyridine-ureas 8a–n were synthesized. All the newly prepared derivatives were evaluated in …

Indonesia's mindset has been focusing on the use of natural medicines, food, and healing
practices widely recognized by the nation's culture. Traditional medicines and herbs used in …

In this study, novel series of sulfonamide derivatives were synthesized starting from 2-
cyanoacetyl) hydrazono) ethyl) phenyl) benzenesulfonamide 4a and 2-cyanoacetyl) …

Herein, a set of pyridine and pyrimidine derivatives were assessed for their impact on the
cell cycle and apoptosis. Human breast cancer (MCF7), hepatocellular carcinoma (HEPG2) …

Designed and synthesized novel homopiperazine linked imidazo [1, 2-a] pyrimidine
derivatives (10a–i, 11a–g, 12), and evaluated them for their in vitro cytotoxicity against HeLa …

A simple and efficient synthetic protocol for the syntheses of spiro pyrano [2, 3-c] pyrazole
and spiro 1, 4-dihydropyridine derivatives via a one pot four-component reaction catalyzed …