[HTML][HTML] Commensal bacteria stimulate antitumor responses via T cell cross-reactivity
Recent studies show gut microbiota modulate antitumor immune responses; one proposed
mechanism is cross-reactivity between antigens expressed in commensal bacteria and …
mechanism is cross-reactivity between antigens expressed in commensal bacteria and …
[HTML][HTML] A public BCR present in a unique dual-receptor-expressing lymphocyte from type 1 diabetes patients encodes a potent T cell autoantigen
T and B cells are the two known lineages of adaptive immune cells. Here, we describe a
previously unknown lymphocyte that is a dual expresser (DE) of TCR and BCR and key …
previously unknown lymphocyte that is a dual expresser (DE) of TCR and BCR and key …
In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers
Nucleic acid aptamers hold great promise for therapeutic applications due to their favorable
intrinsic properties, as well as high-throughput experimental selection techniques. Despite …
intrinsic properties, as well as high-throughput experimental selection techniques. Despite …
Selection of an HLA-C* 03: 04-restricted HIV-1 p24 gag sequence variant is associated with viral escape from KIR2DL3+ natural killer cells: data from an observational …
A Hölzemer, CF Thobakgale, CA Jimenez Cruz… - PLoS …, 2015 - journals.plos.org
Background Viruses can evade immune surveillance, but the underlying mechanisms are
insufficiently understood. Here, we sought to understand the mechanisms by which natural …
insufficiently understood. Here, we sought to understand the mechanisms by which natural …
A mutagenesis study of autoantigen optimization for potential T1D vaccine design
A previously reported autoreactive antigen, termed the X-idiotype, isolated from a unique
cell population in Type 1 diabetes (T1D) patients, was found to stimulate their CD4+ T cells …
cell population in Type 1 diabetes (T1D) patients, was found to stimulate their CD4+ T cells …
Potential interference of graphene nanosheets in immune response via disrupting the recognition of HLA-presented KK10 by TCR: a molecular dynamics simulation …
R Ye, W Song, M Feng, R Zhou - Nanoscale, 2021 - pubs.rsc.org
Graphene and its derivatives have emerged as a promising nanomaterial in biomedical
applications. However, their impact on biosafety continues to be a concern in the field …
applications. However, their impact on biosafety continues to be a concern in the field …
T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable
AV Joglekar, Z Liu, JK Weber… - Proceedings of the …, 2018 - National Acad Sciences
HIV controllers (HCs) are individuals who can naturally control HIV infection, partially due to
potent HIV-specific CD8+ T cell responses. Here, we examined the hypothesis that superior …
potent HIV-specific CD8+ T cell responses. Here, we examined the hypothesis that superior …
Dynamics-based peptide–mhc binding optimization by a convolutional variational autoencoder: a use-case model for Castelo
An unsolved challenge in the development of antigen-specific immunotherapies is
determining the optimal antigens to target. Comprehension of antigen–major …
determining the optimal antigens to target. Comprehension of antigen–major …
T-cell receptor (TCR) clonotype-specific differences in inhibitory activity of HIV-1 cytotoxic T-cell clones is not mediated by TCR alone
NC Flerin, H Chen, TD Glover, PA Lamothe… - Journal of …, 2017 - Am Soc Microbiol
Functional analysis of T-cell responses in HIV-infected individuals has indicated that virus-
specific CD8+ T cells with superior antiviral efficacy are well represented in HIV-1 controllers …
specific CD8+ T cells with superior antiviral efficacy are well represented in HIV-1 controllers …
Binding affinity calculations of gluten peptides to HLA risk modifiers: DQ2. 5 versus DQ7. 5
Free energy perturbation (FEP) calculations can predict relative binding affinities of an
antigen and its point mutants to the same human leukocyte antigen (HLA) with high …
antigen and its point mutants to the same human leukocyte antigen (HLA) with high …