Chemoreceptors are crucial components in the bacterial sensory systems that mediate
chemotaxis. Chemotactic responses exhibit exquisite sensitivity, extensive dynamic range …

Results We carried out sensitive and exhaustive PSI-BLAST searches initiated with the
sequence corresponding to a known structure of the four-helix, ligand-binding domain of the …

The HAMP linker, a predicted structural element observed in many sensor kinases and
methyl-accepting chemotaxis proteins, transmits signals between sensory input modules …

During transmembrane signaling by Escherichia coli Tsr, changes in ligand occupancy in
the periplasmic serine-binding domain promote asymmetric motions in a four-helix …

Two-component systems (TCS) regulate pathogenic commitment in many interactions and
provide an opportunity for unique therapeutic intervention. The VirA/VirG TCS of …

Transmembrane α-helices play a key role in many receptors, transmitting a signal from one
side to the other of the lipid bilayer membrane. Bacterial chemoreceptors are one of the best …

The general secretory (Sec) system of Escherichia coli translocates both periplasmic and
outer membrane proteins through the cytoplasmic membrane. The pathway through the …

Methylation of specific chemoreceptor glutamyl residues by methyltransferase CheR
mediates sensory adaptation and gradient sensing in bacterial chemotaxis. Enzyme action …

Transmembrane signaling of chemotaxis receptors has long been studied, but how the
conformational change induced by ligand binding is transmitted across the bilayer …

Most bacterial chemoreceptors are transmembrane proteins. Although less than 10% of a
transmembrane chemoreceptor is embedded in lipid, separation from the natural membrane …