The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

This article provides an initial assessment of the many risks posed by the COVID-19
pandemic on the conduct of genuine and transparent elections in the world. It begins with …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

Cytosolic DNA is an indicator of pathogen invasion or DNA damage. The cytosolic DNA
sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase …

The SARS-CoV-2 papain-like protease (PLpro), which has deubiquitinating activity,
suppresses the type I interferon (IFN-I) antiviral response. We investigated the mechanism …

A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

Cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS), upon sensing cytosolic
DNA, catalyzes the production of cyclic guanosine monophosphate-adenosine …

Stimulator of interferon genes (STING) is an adaptor protein that is critical for effective innate
antiviral and antitumor immunity. The activity of STING is heavily regulated by protein …