Particle formation using sub-and supercritical fluids

Ž Knez, M Škerget, MK Hrnčič, D Čuček - Supercritical Fluid Technology for …, 2014 - Elsevier
Applying supercritical fluids may overcome the drawbacks of several conventional
processes for formulation of products. For production of particles with micron and submicron …

Numerical simulation of rapid expansion of supercritical carbon dioxide

J Liu, M Do‐Quang, G Amberg - AIChE Journal, 2015 - Wiley Online Library
Axisymmetric rapid expansion of supercritical carbon dioxide is investigated in this article.
The extended generalized Bender equation of state is used to give a good description of the …

Numerical simulation of particle formation in the rapid expansion of supercritical solution process

J Liu, G Amberg, M Do-Quang - The Journal of Supercritical Fluids, 2014 - Elsevier
In this paper, we numerically study particle formation in the rapid expansion of supercritical
solution (RESS) process in a two dimensional, axisymmetric geometry, for a benzoic acid+ …

Particle crystallization by supercritical antisolvent processing techniques: the case of Retama raetam powder for pharmaceutical purposes

A Rejab, H Ksibi - International Journal of Chemical Reactor …, 2023 - degruyter.com
In this work, the Supercritical AntiSolvent process has been used to generate micronized
crystals of Retama raetam. The process was performed using ethanol and CO2 as solvent …

Amoxicillin and ethyl cellulose precipitation by two supercritical antisolvent processes

A Montes, A Nunes, MD Gordillo… - Chemical …, 2013 - Wiley Online Library
Composites of amoxicillin and ethyl cellulose in the micrometer range were precipitated by
supercritical antisolvent (SAS) processes using carbon dioxide as antisolvent and a mixture …

Powder structure transition under the recrystallization conditions in the RESS process

H Ksibi, A Ben Moussa, M Baccar - Chemical Engineering & …, 2006 - Wiley Online Library
A variety of organic substances used in pharmaceutical and agro‐alimentary industries are
often required as fine powders with a controlled size. The RESS process (rapid expansion of …

Simulation of particles transport and coagulation during the RESS process

AB Moussa, H Ksibi, M Baccar - The European Physical Journal …, 2008 - cambridge.org
The rapid expansion of supercritical solution (RESS) is a promising process for the
production of small particles with a narrow size distribution. It involves an expansion of a …

[PDF][PDF] 超临界流体沉淀技术在药剂学中的研究与应用进展

李颖, 杨大坚, 周伟 - 中国药学杂志, 2012 - journal11.magtechjournal.com
目的综述了近年来超临界流体沉淀技术在药剂学中的应用及研究进展, 为超临界流体沉淀的
进一步研究提供参考. 方法根据国内外有关文献, 从几种不同分类的超临界流体沉淀技术分别 …

Experimental Study on Overall Cooling Effectiveness of Turbine Nozzle Guide Vane with Impingement-Cutback Structure

HB He, FF Duan, GC Li - Journal of Applied Fluid Mechanics, 2022 - jafmonline.net
The overall cooling performance of turbine nozzle guide vane, with the impingement-
cutback structure, is experimentally studied in the actual-scale cascade. The gas with the …

Scale-up of solid dispersions

O Kalb, S Page, K Lindenstruth… - Encyclopedia of …, 2013 - api.taylorfrancis.com
The development of pharmaceutical products goes through multiple phases. The main focus
of early development is to develop a formulation that has a high bioavailability and can be …