Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

Elevated protein synthesis is an important feature of many cancer cells and often arises as a
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …

Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …

Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

Translational control plays a critical role in the regulation of gene expression in eukaryotes
and affects many essential cellular processes, including proliferation, apoptosis and …

Myc is one of the most commonly deregulated oncogenes in human cancer, yet therapies
directly targeting Myc hyperactivation are not presently available in the clinic. The …

Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated
protein kinase interacting kinases (MNK) 1/2 are key regulators of mRNA translation …

Cells can rapidly adjust their proteomes in dynamic environments by regulating mRNA
translation. There is mounting evidence that dysregulation of mRNA translation supports the …

Eukaryotic gene expression is a complicated process primarily regulated at the levels of
gene transcription and mRNA translation. The latter involves four main steps: initiation …

Highlights•RNA-binding proteins (RBPs) are essential for tumorigenesis, immune evasion,
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …