A generalized method for analyzing the effects of multiple drugs and for determining
summation, synergism and antagonism has been proposed. The derived, generalized …

This brief perspective article focuses on the most common errors and pitfalls, as well as the
do's and don'ts in drug combination studies, in terms of experimental design, data …

A simple, general and novel method for the quantitative analysis of combined drug effects is
presented. The procedure determines if the drug combinations are additive, synergistic or …

Combinatorial control of biological processes, in which redundancy and multifunctionality
are the norm, fundamentally limits the therapeutic index that can be achieved by even the …

Interactions between agents (drugs, carcinogens, physiological stimuli, environmental
pollutants, etc.) in producing their effects are of fundamental interest and practical …

Despite recent advances in circuit engineering, the design of genetic networks in
mammalian cells is still painstakingly slow and fraught with inexplicable failures. Here, we …

The following simple and generalized equation not involving kinetic constants for substrates
(Km) or inhibitors (Km) describes the summation of the effects of two mutually exclusive and …

Background: Cisplatin-based induction chemotherapy may achieve a complete response
(ie, no sign of tumor following treatment) in 70%-80% of patients with germ cell tumors …

We demonstrate here that cytarabine and daunorubicin, a standard drug combination used
in the treatment of leukaemia, exhibits drug ratio-dependent synergistic antitumor activity in …

This brief review provides a practical guide for drug combination studies and delineates its
essence in terms of the mass-action-based theory, experimental design and automated …