Malaria is a long-standing public health problem in sub-Saharan Africa, whereas arthropod-
borne viruses (arboviruses) such as dengue and chikungunya cause an under-recognised …

P. berghei ANKA infection in CBA or CB57BL/6 mice is used widely as a murine 'model'of
human cerebral malaria (HCM), despite markedly different histopathological features. The …

Background Severe malaria is a major cause of childhood death and often the main reason
for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established …

Severe acute malnutrition (SAM) is associated with increased severity of common infectious
diseases, and death amongst children with SAM is almost always as a result of infection …

Background Malaria over-diagnosis in Africa is widespread and costly both financially and in
terms of morbidity and mortality from missed diagnoses. An understanding of the reasons …

Failure to establish an appropriate balance between pro-and anti-inflammatory immune
responses is believed to contribute to pathogenesis of severe malaria. To determine …

Malaria rapid diagnostic tests (RDTs) are instrument-free tests that provide results within 20
min and can be used by community health workers. RDTs detect antigens produced by the …

Antimalarial drugs have usually been first deployed in areas of malaria endemicity at doses
which were too low, particularly for high-risk groups such as young children and pregnant …

Background Plasmodium vivax causes almost half of all malaria cases in Asia and is
recognised as a significant cause of morbidity. In recent years it has been associated with …

The World Health Organization (WHO) has developed a global roadmap to defeat meningitis
by 2030. To advocate for and track progress of the roadmap, the burden of meningitis as a …