Zinc (Zn) is the second most abundant trace element in human, which can't be stored in the
body, thus regular dietary intake is required. This review explained the physiological and …

The biggest drawback of a current diabetes therapy is the treatment of the consequences not
the cause of the disease. Regardless of the diabetes type, preservation and recovery of …

Current genome-editing systems generally rely on inducing DNA double-strand breaks
(DSBs). This may limit their utility in clinical therapies, as unwanted mutations caused by …

DNA hypermethylation at the promoter of tumour-suppressor genes is tightly correlated with
their transcriptional repression and recognized as the hallmark of majority of cancers …

DNA methylation plays a critical role in the regulation and maintenance of cell-type specific
transcriptional programs. Targeted epigenome editing is an emerging technology to …

Histone modifications reflect gene activity, but the relationship between cause and
consequence of transcriptional control is heavily debated. Recent developments in rewriting …

Detection of DNA methylation in the genome has been possible for decades; however, the
ability to deliberately and specifically manipulate local DNA methylation states in the …

Epigenome editing refers to the directed alteration of chromatin marks at specific genomic
loci by using targeted EpiEffectors which comprise designed DNA recognition domains (zinc …

Advances in genome engineering technologies have made the precise control over genome
sequence and regulation possible across a variety of disciplines. These tools can expand …

It is possible to target individual sequence motives within genomes by using synthetic DNA‐
binding domains. This one‐dimensional approach has been used successfully in plants to …