Targeting metabolism for cancer therapy

A Luengo, DY Gui, MG Vander Heiden - Cell chemical biology, 2017 - cell.com
Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …

Applications of nanobodies in brain diseases

F Zheng, Y Pang, L Li, Y Pang, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Nanobodies are antibody fragments derived from camelids, naturally endowed with
properties like low molecular weight, high affinity and low immunogenicity, which contribute …

COVID‐19‐related encephalopathy: a case series with brain FDG‐positron‐emission tomography/computed tomography findings

C Delorme, O Paccoud, A Kas… - European journal of …, 2020 - Wiley Online Library
Aim The aim of this paper is to describe the clinical features of COVID‐19‐related
encephalopathy and their metabolic correlates using brain 2‐desoxy‐2‐fluoro‐D‐glucose …

[HTML][HTML] Quantifying normal human brain metabolism using hyperpolarized [1–13C] pyruvate and magnetic resonance imaging

JT Grist, MA McLean, F Riemer, RF Schulte, SS Deen… - Neuroimage, 2019 - Elsevier
Abstract Hyperpolarized 13 C Magnetic Resonance Imaging (13 C-MRI) provides a highly
sensitive tool to probe tissue metabolism in vivo and has recently been translated into …

Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress

ML Cooper, S Pasini, WS Lambert… - Proceedings of the …, 2020 - National Acad Sciences
In the central nervous system, glycogen-derived bioenergetic resources in astrocytes help
promote tissue survival in response to focal neuronal stress. However, our understanding of …

Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery

L Mosconi, V Berti, C Guyara-Quinn, P McHugh… - PloS one, 2017 - journals.plos.org
After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The
biological mechanisms underlying the increased AD risk in women remain largely …

Imaging and neuropathological findings in patients with post COVID-19 neurological syndrome—a review

J Okrzeja, A Garkowski, B Kubas… - Frontiers in …, 2023 - frontiersin.org
Post COVID-19 syndrome is determined as signs and symptoms that appear during or after
an infection consistent with SARS-CoV-2 disease, persist for more than 12 weeks and are …

18F-FDG-PET Imaging for Post-COVID-19 Brain and Skeletal Muscle Alterations

T Rudroff, CD Workman, LLB Ponto - Viruses, 2021 - mdpi.com
Scientific evidence concerning the subacute and long-term effects of coronavirus disease
2019 (COVID-19) is on the rise. It has been established that infection by serious acute …

[HTML][HTML] Intensity normalization methods in brain FDG-PET quantification

FJ López-González, J Silva-Rodríguez… - Neuroimage, 2020 - Elsevier
Background The lack of standardization of intensity normalization methods and its unknown
effect on the quantification output is recognized as a major drawback for the harmonization …

The role of nutrition in cognitive function and brain ageing in the elderly

SL Gardener, SR Rainey-Smith - Current nutrition reports, 2018 - Springer
Abstract Purpose of Review The purposes of this review were to examine literature
published over the last 5 years and to evaluate the role of nutrition in cognitive function and …