Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications

K Kitsou, P Lagiou, G Magiorkinis - Journal of Medical Virology, 2023 - Wiley Online Library
Abstract Human Endogenous Retroviruses (HERVs) are viral sequences integrated into the
human genome, resulting from the infection of human germ‐line cells by ancient exogenous …

[HTML][HTML] Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma

AH Shah, SR Rivas, TT Doucet-O'Hare… - The Journal of …, 2023 - Am Soc Clin Investig
Human endogenous retroviruses (HERVs) are ancestral viral relics that constitute nearly 8%
of the human genome. Although normally silenced, the most recently integrated provirus …

Cancer stem cell mimicry for immune evasion and therapeutic resistance

PE Saw, Q Liu, PP Wong, E Song - Cell Stem Cell, 2024 - cell.com
Cancer stem cells (CSCs) are heterogeneous, possess self-renewal attributes, and
orchestrate important crosstalk in tumors. We propose that the CSC state represents" …

[HTML][HTML] Identification of differentially expressed HERV-K (HML-2) loci in colorectal cancer

Q Kang, X Guo, T Li, C Yang, J Han, L Jia… - Frontiers in …, 2023 - frontiersin.org
Colorectal cancer is one of the malignant tumors with the highest mortality rate in the world.
Survival rates vary significantly among patients at various stages of the disease. A biomarker …

[HTML][HTML] Mechanistic regulation of HERV activation in tumors and implications for translational research in oncology

EA Cherkasova, L Chen, RW Childs - Frontiers in Cellular and …, 2024 - frontiersin.org
Transcription of distinct loci of human endogenous retroviruses (HERVs) and in some cases,
translation of these transcripts have been consistently observed in many types of cancer. It is …

[HTML][HTML] Epigenetic regulation in primary CNS tumors: an opportunity to bridge old and new WHO classifications

DD Dang, JS Rosenblum, AH Shah, Z Zhuang… - Cancers, 2023 - mdpi.com
Simple Summary In this review, the authors re-evaluate the fifth edition of the World Health
Organization Classification of Central Nervous System tumors in light of recent advances in …

[HTML][HTML] Does the interplay between human endogenous retrovirus K and extracellular vesicles contribute to aging?

C DeMarino, A Nath, Z Zhuang… - … vesicles and circulating …, 2023 - ncbi.nlm.nih.gov
The role of extracellular vesicles (EVs), including retroviral-like particles (RVLPs), in
pathogenic processes is currently a subject of active investigation. Several studies have …

[HTML][HTML] Alternative and aberrant splicing of human endogenous retroviruses in cancer. What about head and neck?—A mini review

L Agoni - Frontiers in Oncology, 2022 - frontiersin.org
Human endogenous retroviruses (HERVs) are transcribed in many cancer types, including
head and neck cancer. Because of accumulating mutations at proviral loci over evolutionary …

[HTML][HTML] Interplay between Viruses and Endogenous Retroviruses in Immune Response and Diseases Affecting the Nervous System

C Römer - Viral Replication Cycle-From Pathogenesis and …, 2023 - intechopen.com
Endogenous retroviruses are integral part of the human genome. Endogenous retroviruses
are integral parts of human genome that originate from waves of retroviral infections of …