Therapeutic targets in lung tissue remodelling and fibrosis
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
Untangling asthma phenotypes and endotypes
Asthma phenotypes have been developed to address the complexities of the disease.
However, owing to a lack of longitudinal studies, little is known about the onset as well as …
However, owing to a lack of longitudinal studies, little is known about the onset as well as …
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma
J Bousquet, E Mantzouranis, AA Cruz… - Journal of Allergy and …, 2010 - Elsevier
Asthma is a global health problem affecting around 300 million individuals of all ages, ethnic
groups and countries. It is estimated that around 250,000 people die prematurely each year …
groups and countries. It is estimated that around 250,000 people die prematurely each year …
Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
GP Anderson - The Lancet, 2008 - thelancet.com
Clinical asthma is very widely assumed to be the net result of excessive inflammation driven
by aberrant T-helper-2 (Th2) immunity that leads to inflamed, remodelled airways and then …
by aberrant T-helper-2 (Th2) immunity that leads to inflamed, remodelled airways and then …
The sentinel role of the airway epithelium in asthma pathogenesis
ST Holgate - Immunological reviews, 2011 - Wiley Online Library
The adoption of the concept that asthma is primarily a disease most frequently associated
with elaboration of T‐helper 2 (Th2)‐type inflammation has led to the widely held concept …
with elaboration of T‐helper 2 (Th2)‐type inflammation has led to the widely held concept …
Pediatric severe asthma is characterized by eosinophilia and remodeling without TH2 cytokines
BACKGROUND: The pathology of pediatric severe therapy-resistant asthma (STRA) is little
understood. OBJECTIVES: We hypothesized that STRA in children is characterized by …
understood. OBJECTIVES: We hypothesized that STRA in children is characterized by …
Bidirectional interaction of airway epithelial remodeling and inflammation in asthma
Asthma is a chronic disease of the airways that has long been viewed predominately as an
inflammatory condition. Accordingly, current therapeutic interventions focus primarily on …
inflammatory condition. Accordingly, current therapeutic interventions focus primarily on …
Recurrent severe preschool wheeze: from prespecified diagnostic labels to underlying endotypes
PFM Robinson, S Fontanella, S Ananth… - American journal of …, 2021 - atsjournals.org
Rationale: Preschool wheezing is heterogeneous, but the underlying mechanisms are
poorly understood. Objectives: To investigate lower airway inflammation and infection in …
poorly understood. Objectives: To investigate lower airway inflammation and infection in …
The potential of biologics for the treatment of asthma
G Pelaia, A Vatrella, R Maselli - Nature reviews Drug discovery, 2012 - nature.com
Recent advances in the knowledge of asthma pathobiology suggest that biological therapies
that target cytokines can be potentially useful for the treatment of this complex and …
that target cytokines can be potentially useful for the treatment of this complex and …
A new look at the pathogenesis of asthma
Asthma is an inflammatory disorder of the conducting airways that has strong association
with allergic sensitization. The disease is characterized by a polarized Th-2 (T-helper-2) …
with allergic sensitization. The disease is characterized by a polarized Th-2 (T-helper-2) …