Simple Summary The Tribbles proteins are members of CAMK Ser/Thr protein kinase family.
They are evolutionary conserved pseudokinases found in most tissues of eukaryotic …

Prostate cancer (PCa) continues to be a major health concern worldwide, with its resistance
to chemotherapy and radiation therapy presenting major hurdles in successful treatment …

The pseudokinase TRIB1 controls cell function in a range of contexts, by regulating MAP
kinase activation and mediating protein degradation via the COP1 ubiquitin ligase. TRIB1 …

Exosomal circular RNA was found to mediate cancer chemoresistance. However, whether
exosomal circRNA Scm-like with four malignant brain tumor domains 2 (circ-SFMBT2) was …

Simple Summary Tribbles proteins play various roles in cancer initiation and progression.
However, still little is known about their molecular actions. Here we developed a mass …

Breast cancer (BCa) is a major global health challenge. The BCa genome often carries
extensive somatic copy number alterations (CNAs), including gains/amplifications and …

Simple Summary TRIB1 is at the center of major cell signaling pathways. In this review, we
describe its role in immune cells and highlight TRIB1 interacting partners which suggests …

Simple Summary Pseudokinases have evolved from conventional kinases and differ from
them in their inability to phosphorylate their substrates. The Tribbles pseudokinases have …

Abstract Tribbles homolog 1 (TRIB1) is a member of the tribbles family of pseudoprotein
kinases and is widely expressed in numerous tissues, such as bone marrow, skeletal …

MicroRNAs (miRNAs) have emerged as important regulators of gene expression, and the
deregulation of their activity has been linked to the onset and progression of a variety of …