Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Patient-derived organoids (PDO) are a new biomedical research model that can reconstruct
phenotypic and genetic characteristics of the original tissue and are useful for research on …

Cardiovascular diseases are a leading cause of death worldwide. Current treatments
directed at heart repair have several disadvantages, such as a lack of donors for heart …

Cardiac organoids are 3-dimensional (3D) structures composed of tissue or niche-specific
cells, obtained from diverse sources, encapsulated in either a naturally derived or synthetic …

Background: During cardiomyocyte maturation, the centrosome, which functions as a
microtubule organizing center in cardiomyocytes, undergoes dramatic structural …

Branchiomeric muscles of the head and neck originate in a population of cranial mesoderm
termed cardiopharyngeal mesoderm that also contains progenitor cells contributing to …

Congenital heart defects (CHD) constitute the most common type of birth defect in humans.
Maternal diabetes during the first trimester of pregnancy (pregestational diabetes, or PGD) is …

Cardiovascular diseases cause significant morbidity and mortality worldwide. Engineered
cardiac organoids are being developed and used to replicate cardiac tissues supporting …

After more than 20 years following the introduction of regenerative medicine to address the
problem of cardiac diseases, still questions arise as to the best cell types and materials to …

In recent years, significant biotechnological advancements have been made in engineering
human cardiac tissues and organ-like models. This field of research is crucial for both basic …