In it for the long run: perspectives on exploiting long-read sequencing in livestock for population scale studies of structural variants
TV Nguyen, CJ Vander Jagt, J Wang… - Genetics Selection …, 2023 - Springer
Studies have demonstrated that structural variants (SV) play a substantial role in the
evolution of species and have an impact on Mendelian traits in the genome. However, unlike …
evolution of species and have an impact on Mendelian traits in the genome. However, unlike …
Structural variant-based pangenome construction has low sensitivity to variability of haplotype-resolved bovine assemblies
Advantages of pangenomes over linear reference assemblies for genome research have
recently been established. However, potential effects of sequence platform and assembly …
recently been established. However, potential effects of sequence platform and assembly …
Molecular cytogenetics in domestic bovids: A review
A Iannuzzi, L Iannuzzi, P Parma - Animals, 2023 - mdpi.com
Simple Summary Molecular cytogenetics, and particularly the use of fluorescence in situ
hybridization (FISH), has allowed deeper investigation of the chromosomes of domestic …
hybridization (FISH), has allowed deeper investigation of the chromosomes of domestic …
[HTML][HTML] Genome-wide association analyses reveal copy number variant regions associated with reproduction and disease traits in Canadian Holstein cattle
HR de Oliveira, TCS Chud, GA Oliveira Jr… - Journal of dairy …, 2024 - Elsevier
This study aimed to evaluate the impact of copy number variants (CNV) on 13 reproduction
and 12 disease traits in Holstein cattle. Intensity signal files containing log R ratio and B …
and 12 disease traits in Holstein cattle. Intensity signal files containing log R ratio and B …
Genome-wide detection of copy number variation in American mink using whole-genome sequencing
Abstract Background Copy number variations (CNVs) represent a major source of genetic
diversity and contribute to the phenotypic variation of economically important traits in …
diversity and contribute to the phenotypic variation of economically important traits in …
[HTML][HTML] Genome-wide association study between copy number variants and hoof health traits in Holstein dairy cattle
Genome-wide association studies based on SNP have been completed for multiple traits in
dairy cattle; however, copy number variants (CNV) could add genomic information that has …
dairy cattle; however, copy number variants (CNV) could add genomic information that has …
A large structural variant collection in Holstein cattle and associated database for variant discovery, characterization, and application
Abstract Background Structural variants (SVs) such as deletions, duplications, and insertions
are known to contribute to phenotypic variation but remain challenging to identify and …
are known to contribute to phenotypic variation but remain challenging to identify and …
Investigating the effect of imputed structural variants from whole-genome sequence on genome-wide association and genomic prediction in dairy cattle
Simple Summary Structural variants are large changes to the DNA sequences that differ
from individual to individual. We discovered and quality-controlled a set of 24,908 structural …
from individual to individual. We discovered and quality-controlled a set of 24,908 structural …
Identification of copy number variations in the genome of Dairy Gir cattle
Studying structural variants that can control complex traits is relevant for dairy cattle
production, especially for animals that are tolerant to breeding conditions in the tropics, such …
production, especially for animals that are tolerant to breeding conditions in the tropics, such …
Discovering copy number variation in dual-purpose Xinjiang brown cattle
J Zhou, L Liu, E Reynolds, X Huang, D Garrick… - Frontiers in …, 2022 - frontiersin.org
Copy number variants (CNVs), which are a class of structural variant, can be important in
relating genomic variation to phenotype. The primary aims of this study were to discover the …
relating genomic variation to phenotype. The primary aims of this study were to discover the …