A synaptic perspective of fragile X syndrome and autism spectrum disorders

C Bagni, RS Zukin - Neuron, 2019 - cell.com
Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

EEG as a translational biomarker and outcome measure in fragile X syndrome

A Kenny, D Wright, AC Stanfield - Translational Psychiatry, 2022 - nature.com
Targeted treatments for fragile X syndrome (FXS) have frequently failed to show efficacy in
clinical testing, despite success at the preclinical stages. This has highlighted the need for …

Emergence and rate of autism in fragile X syndrome across the first years of life

JE Roberts, J Bradshaw, E Will, AL Hogan… - Development and …, 2020 - cambridge.org
Prospective longitudinal studies of idiopathic autism spectrum disorder (ASD) have provided
insights into early symptoms and predictors of ASD during infancy, well before ASD can be …

Communication in fragile X syndrome: patterns and implications for assessment and intervention

A Hoffmann - Frontiers in psychology, 2022 - frontiersin.org
Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability and is
associated with a high rate of autism diagnosis. Language delays have been noted in the …

Neural correlates of auditory hypersensitivity in fragile X syndrome

KA Razak, DK Binder, IM Ethell - Frontiers in Psychiatry, 2021 - frontiersin.org
The mechanisms underlying the common association between autism spectrum disorders
(ASD) and sensory processing disorders (SPD) are unclear, and treatment options to reduce …

Pragmatic profiles of adults with Fragile X syndrome and Williams syndrome

E Diez-Itza, A Viejo, M Fernández-Urquiza - Brain Sciences, 2022 - mdpi.com
Linguistic phenotypes of individuals with Fragile X (FXS) and Williams (WS) syndromes
exhibit various degrees of pragmatic impairment, involving difficulties in social …

A randomized controlled trial of sertraline in young children with autism spectrum disorder

LA Potter, DA Scholze, HMB Biag, A Schneider… - Frontiers in …, 2019 - frontiersin.org
Objective: Selective serotonin reuptake inhibitors like sertraline have been shown in
observational studies and anecdotal reports to improve language development in young …

Psychometrics of the pragmatic rating scale for school-age children with a range of linguistic and social communication skills

E Dillon, C Holingue, D Herman, RJ Landa - Journal of Speech, Language …, 2021 - ASHA
Purpose Social communication or pragmatic skills are continuously distributed in the
general population. Impairment in these skills is associated with two clinical disorders …

Predictors, parental views, and concordance across diagnostic sources of autism in male youth with fragile X syndrome: clinical best estimate and community …

J Klusek, E Will, C Moser, K Hills, AJ Thurman… - Research on Child and …, 2023 - Springer
Persons with fragile X syndrome (FXS) with cooccurring autism spectrum disorder (ASD) are
at risk for poorer educational, medical, employment, and independent living outcomes. Thus …

Autism symptoms in children and young adults with fragile x syndrome, angelman syndrome, tuberous sclerosis complex, and neurofibromatosis type 1: a cross …

K Lubbers, EM Stijl, B Dierckx, DA Hagenaar… - Frontiers in …, 2022 - frontiersin.org
Objective The etiology of autism spectrum disorder (ASD) remains unclear, due to genetic
heterogeneity and heterogeneity in symptoms across individuals. This study compares ASD …