Molecular mechanisms of transgenerational epigenetic inheritance

MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

[HTML][HTML] The hypothalamic-pituitary-adrenal axis: development, programming actions of hormones, and maternal-fetal interactions

JA Sheng, NJ Bales, SA Myers, AI Bautista… - Frontiers in behavioral …, 2021 - frontiersin.org
The hypothalamic-pituitary adrenal axis is a complex system of neuroendocrine pathways
and feedback loops that function to maintain physiological homeostasis. Abnormal …

Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms

R Yehuda, A Lehrner - World psychiatry, 2018 - Wiley Online Library
This paper reviews the research evidence concerning the intergenerational transmission of
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …

Intergenerational and transgenerational epigenetic inheritance in animals

MF Perez, B Lehner - Nature cell biology, 2019 - nature.com
Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …

Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility

NE Skakkebaek, E Rajpert-De Meyts… - Physiological …, 2016 - journals.physiology.org
It is predicted that Japan and European Union will soon experience appreciable decreases
in their populations due to persistently low total fertility rates (TFR) below replacement level …

Holocaust exposure induced intergenerational effects on FKBP5 methylation

R Yehuda, NP Daskalakis, LM Bierer, HN Bader… - Biological …, 2016 - Elsevier
Background The involvement of epigenetic mechanisms in intergenerational transmission of
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …

Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

Q Chen, W Yan, E Duan - Nature Reviews Genetics, 2016 - nature.com
Once deemed heretical, emerging evidence now supports the notion that the inheritance of
acquired characteristics can occur through ancestral exposures or experiences and that …

Intergenerational transmission of self-regulation: A multidisciplinary review and integrative conceptual framework.

DJ Bridgett, NM Burt, ES Edwards… - Psychological …, 2015 - psycnet.apa.org
This review examines mechanisms contributing to the intergenerational transmission of self-
regulation. To provide an integrated account of how self-regulation is transmitted across …

Exploring the evidence for epigenetic regulation of environmental influences on child health across generations

CV Breton, R Landon, LG Kahn, MB Enlow… - Communications …, 2021 - nature.com
Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

Intergenerational transmission of stress in humans

ME Bowers, R Yehuda - Neuropsychopharmacology, 2016 - nature.com
The hypothesis that offspring are affected by parental trauma or stress exposure, first noted
anecdotally, is now supported empirically by data from Holocaust survivor offspring cohorts …