Telomeres and telomere length: a general overview

N Srinivas, S Rachakonda, R Kumar - Cancers, 2020 - mdpi.com
Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Role of telomere length in human carcinogenesis

A Tsatsakis, T Oikonomopoulou… - International …, 2023 - spandidos-publications.com
Cancer is considered the most important clinical, social and economic issue regarding
cause‑specific disability‑adjusted life years among all human pathologies. Exogenous …

The telomere world and aging: Analytical challenges and future perspectives

E Mensà, S Latini, D Ramini, G Storci, M Bonafè… - Ageing research …, 2019 - Elsevier
Telomeres, the terminal nucleoprotein structures of eukaryotic chromosomes, play
pleiotropic functions in cellular and organismal aging. Telomere length (TL) varies …

The genomic landscape of melanoma and its therapeutic implications

TT Yang, S Yu, CLK Ke, ST Cheng - Genes, 2023 - mdpi.com
Melanoma is one of the most aggressive malignancies of the skin. The genetic composition
of melanoma is complex and varies among different subtypes. With the aid of recent …

Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis

M Kroupa, SK Rachakonda, V Liska, N Srinivas… - British journal of …, 2019 - nature.com
Background Telomeres, repetitive DNA capping ends of eukaryotic chromosomes, are
important in the maintenance of genomic integrity. Perturbed telomeres are common …

Telomere length, arsenic exposure and risk of basal cell carcinoma of skin

N Srinivas, S Rachakonda, T Hielscher… - …, 2019 - academic.oup.com
Telomere length per se a heritable trait has been reported to be associated with different
diseases including cancers. In this study, based on arsenic-exposed 528 cases with basal …

Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting

M Seviiri, RA Scolyer, DT Bishop… - Journal of Translational …, 2022 - Springer
Background The role of germline genetic factors in determining survival from cutaneous
melanoma (CM) is not well understood. Objective To perform a genome-wide association …

Race differences in telomere length in benign prostate biopsies and subsequent risk of prostate cancer

BA Rybicki, SM Sadasivan, Y Chen, I Loveless… - … Biomarkers & Prevention, 2022 - AACR
Background: Telomere shortening is linked to aging and may be associated with increased
risk for cancer. Most cancer studies have used telomere length in leukocytes rather than in …

Leukocyte telomere length is associated with aggressive prostate cancer in localized prostate cancer patients

J Xu, WS Chang, CW Tsai, DT Bau, Y Xu, JW Davis… - …, 2020 - thelancet.com
Background Telomeres play important roles in cancer initiation and progression. The aim of
this study is to investigate whether leukocyte telomere length (LTL) is associated with …

[HTML][HTML] Current Insights into the Role of UV Radiation-Induced Oxidative Stress in Melanoma Pathogenesis

E Gieniusz, E Skrzydlewska, W Łuczaj - International Journal of …, 2024 - mdpi.com
Cutaneous melanoma accounts for the majority of skin cancer-related deaths, and its
incidence increases each year. The growing number of melanoma cases, especially in …