Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

Diabetic nephropathy is a well-known complication of diabetes and is a leading cause of
chronic renal failure in the Western world. It is characterized by the accumulation of …

Abstract NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein
(TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in …

Renal tubular epithelial cells (RTECs) are one of the most mitochondria-rich cell types, and
are thus vulnerable to mitochondrial dysregulation, which is defined as a pivotal event in …

We examined the effects of empagliflozin, a selective inhibitor of Na+-glucose cotransporter
2, on mitochondrial quality control and autophagy in renal tubular cells in a diabetic …

Mitochondria are a class of dynamic organelles that constantly undergo fission and fusion.
Mitochondrial dynamics is governed by a complex molecular machinery and finely tuned by …

Diabetic kidney disease (DKD) is associated with oxidative stress and mitochondrial injury.
Myo-inositol oxygenase (MIOX), a tubular-specific enzyme, modulates redox imbalance and …

Chronic kidney disease (CKD) is one of the fastest growing causes of death worldwide,
emphasizing the need to develop novel therapeutic approaches. CKD predisposes to acute …

Diabetic Nephropathy (DN) is believed to be a major microvascular complication of
diabetes. The hallmark of DN includes deposition of Extracellular Matrix (ECM) proteins …

Diabetic nephropathy (DN) is a progressive microvascular complication arising from
diabetes. Within the kidney, the glomeruli, tubules, vessels and interstitium are disrupted …