Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide
mimetics. Salient features include the stability of hybridization complexes (either as …
mimetics. Salient features include the stability of hybridization complexes (either as …
Programmable and multifunctional DNA‐based materials for biomedical applications
DNA encodes the genetic information; recently, it has also become a key player in material
science. Given the specific Watson–Crick base‐pairing interactions between only four types …
science. Given the specific Watson–Crick base‐pairing interactions between only four types …
Diagnosis of bloodstream infections: an evolution of technologies towards accurate and rapid identification and antibiotic susceptibility testing
Bloodstream infections (BSI) are a leading cause of death worldwide. The lack of timely and
reliable diagnostic practices is an ongoing issue for managing BSI. The current gold …
reliable diagnostic practices is an ongoing issue for managing BSI. The current gold …
Atom transfer radical polymerization for biorelated hybrid materials
Proteins, nucleic acids, lipid vesicles, and carbohydrates are the major classes of
biomacromolecules that function to sustain life. Biology also uses post-translation …
biomacromolecules that function to sustain life. Biology also uses post-translation …
Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications
C Suparpprom, T Vilaivan - RSC Chemical Biology, 2022 - pubs.rsc.org
Peptide nucleic acid or PNA is a synthetic DNA mimic that contains a sequence of
nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine. The …
nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine. The …
A minimal hybridization chain reaction (HCR) system using peptide nucleic acids
KT Kim, S Angerani, N Winssinger - Chemical Science, 2021 - pubs.rsc.org
The HCR represents a powerful tool for amplification in DNA-based circuitry and sensing
applications, yet requires the use of long DNA sequences to grant hairpin metastability. Here …
applications, yet requires the use of long DNA sequences to grant hairpin metastability. Here …
Biosupramolecular systems: integrating cues into responses
Life is orchestrated by biomolecules interacting in complex networks of biological circuitry
with emerging function. Progress in different areas of chemistry has made the design of …
with emerging function. Progress in different areas of chemistry has made the design of …
Orthogonal amplification circuits composed of acyclic nucleic acids enable RNA detection
Y Chen, R Nagao, K Murayama… - Journal of the American …, 2022 - ACS Publications
Construction of complex DNA circuits is difficult due to unintended hybridization and
degradation by enzymes under biological conditions. We herein report a hybridization chain …
degradation by enzymes under biological conditions. We herein report a hybridization chain …
DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid
Peptide nucleic acids (PNAs) can target and stimulate recombination reactions in genomic
DNA. We have reported that γPNA oligomers possessing the diethylene glycol γ-substituent …
DNA. We have reported that γPNA oligomers possessing the diethylene glycol γ-substituent …
Xeno nucleic acids (XNAs) having non-ribose scaffolds with unique supramolecular properties
DNA and RNA have significance as genetic materials, therapeutic potential, and
supramolecular properties. Advances in nucleic acid chemistry have enabled large-scale …
supramolecular properties. Advances in nucleic acid chemistry have enabled large-scale …