Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …

Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is
present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

The epithelial lining of the airway forms the first barrier against environmental insults, such
as inhaled cigarette smoke, which is the primary risk factor for the development of chronic …

Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome associated
with abnormal inflammatory immune responses of the lung to noxious particles and gases …

The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a
worldwide health care burden, approaching that imposed by transmittable infectious …

Pulmonary epithelial cells are widely considered to be the first line of defence in the lung
and are responsible for coordinating the innate immune response to injury and subsequent …

The receptor for advanced glycation endproducts (RAGE) is a pro-inflammatory pattern
recognition receptor (PRR) that has been implicated in the pathogenesis of numerous …

The primary function of the bronchial epithelium is to act as a defensive barrier aiding the
maintenance of normal airway function. Bronchial epithelial cells (BEC) form the interface …