A review of respiratory anatomical development, air flow characterization and particle deposition
The understanding of complex inhalation and transport processes of pollutant particles
through the human respiratory system is important for investigations into dosimetry and …
through the human respiratory system is important for investigations into dosimetry and …
[HTML][HTML] Patient-specific organoid and organ-on-a-chip: 3D cell-culture meets 3D printing and numerical simulation
The last few decades have witnessed diversified in vitro models to recapitulate the
architecture and function of living organs or tissues and contribute immensely to advances in …
architecture and function of living organs or tissues and contribute immensely to advances in …
Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety
A Chramiec, D Teles, K Yeager, A Marturano-Kruik… - Lab on a Chip, 2020 - pubs.rsc.org
Traditional drug screening models are often unable to faithfully recapitulate human
physiology in health and disease, motivating the development of microfluidic organs-on-a …
physiology in health and disease, motivating the development of microfluidic organs-on-a …
Tutorial: Understanding the transport, deposition, and translocation of particles in human respiratory systems using Computational Fluid-Particle Dynamics and …
Dynamic modeling of how particulate matter (PM) transport, deposit, and translocate from
human respiratory systems to systemic regions subject to indoor and outdoor exposures are …
human respiratory systems to systemic regions subject to indoor and outdoor exposures are …
Pharmaceutical aerosols deposition patterns from a Dry Powder Inhaler: Euler Lagrangian prediction and validation
Abstract This study uses Computational Fluid Dynamics (CFD) to predict, analyze and
validate the deposition patterns in a human lung for a Budesonide drug delivered from the …
validate the deposition patterns in a human lung for a Budesonide drug delivered from the …
Euler–Lagrange approach to investigate respiratory anatomical shape effects on aerosol particle transport and deposition
An accurate knowledge of the pulmonary aerosol particle transport in the realistic lung is
essential to deliver the therapeutic particle to the targeted site of the bifurcating airways. The …
essential to deliver the therapeutic particle to the targeted site of the bifurcating airways. The …
Air conditioning analysis among human nasal passages with anterior anatomical variations
A major functional role of the nasal cavity is air conditioning of the inspired environmental air
to near alveolar conditions. It is well known that the anatomical disparities among nasal …
to near alveolar conditions. It is well known that the anatomical disparities among nasal …
In Silico Methods for Development of Generic Drug–Device Combination Orally Inhaled Drug Products
RL Walenga, AH Babiskin… - CPT: pharmacometrics & …, 2019 - Wiley Online Library
The development of generic, single‐entity, drug–device combination products for orally
inhaled drug products is challenging in part because of the complex nature of device design …
inhaled drug products is challenging in part because of the complex nature of device design …
Predicting particle deposition in an adult human lung using an oscillatory, lumped respiratory model
Inhalation has become widely accepted as the optimal drug delivery mechanism for
respiratory diseases, which often requires targeting a particular region of the lung …
respiratory diseases, which often requires targeting a particular region of the lung …
Innovation for generic drugs: science and research under the generic drug user fee amendments of 2012
RA Lionberger - Clinical Pharmacology & Therapeutics, 2019 - Wiley Online Library
Regulatory science is science and research intended to improve decision making in a
regulatory framework. Improvements in decision making can be in both accuracy (making …
regulatory framework. Improvements in decision making can be in both accuracy (making …