Oxidized phospholipids that result from tissue injury operate as immunomodulatory signals
that, depending on the context, lead to proinflammatory or anti-inflammatory responses. In …

Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour
microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and …

Macrophages, the central mediators of innate immune responses, being in the first-line of
defense, they have to readily respond to pathogenic or tissue damage signals to initiate the …

Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory
and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown …

Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory
gene expression to changes in macrophage metabolism, both of which influence …

Acetyl-CoA carboxylase (ACC) regulates lipid synthesis; however, its role in inflammatory
regulation in macrophages remains unclear. We generated mice that are deficient in both …

Obesity exhibits a correlation with metabolic inflammation and endoplasmic reticulum stress,
promoting the progression of metabolic disease such as diabetes, hyperlipidemia …

Ceramides are bioactive sphingolipids that support the structure of the plasma membrane
and mediate numerous cell-signaling events in eukaryotic cells. The finding that ceramides …

Innate and adaptive immunity participate in and regulate numerous human diseases.
Increasing evidence implies that metabolic reprogramming mediates immune cell functional …

Background Oxidative stress and inflammation contribute to the etiopathogenesis of several
human chronic diseases, such as cancer, diabetes, cardiovascular diseases and metabolic …