The coordinated expression of the Hox gene family encoding transcription factors is critical
for proper embryonic development and patterning. Major efforts have thus been dedicated to …

Polycomb complexes regulate cell type–specific gene expression programs through
heritable silencing of target genes. Trimethylation of histone H3 lysine 27 (H3K27me3) is …

Objective Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic
islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In …

The dual nature of pancreatic tissue permits both endocrine and exocrine functions.
Enzymatic secretions by the exocrine pancreas help digestive processes while the …

Background High throughput sequencing has enabled the interrogation of the transcriptomic
landscape of glucagon-secreting alpha cells, insulin-secreting beta cells, and somatostatin …

The pancreas is a central organ for human diseases. Most alleles uncovered by genome-
wide association studies of pancreatic dysfunction traits overlap with non-coding sequences …

For almost 40 years, pronuclear DNA injection represents the standard method to generate
transgenic mice with random integration of transgenes. Such a routine procedure is widely …

Development requires the expression of master regulatory genes necessary to specify a cell
lineage. Equally significant is the stable and heritable silencing of master regulators that …

Objective: Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic
islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In …

The potential to use human pluripotent stem cells in regenerative medicine is an idea that
continues to excite and captivate much of the science community, decades after the initial …