DNA-encoded chemical libraries (DELs) represent a versatile and powerful technology
platform for the discovery of small-molecule ligands to protein targets of biological and …

The development of bioactive small molecules as probes or drug candidates requires
discovery platforms that enable access to chemical diversity and can quickly reveal new …

Over the past decade, DNA-encoded libraries (DELs) have emerged as a leading platform
for small molecule drug discovery among pharmaceutical companies, biotech companies …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4
million humans globally, but there is no bona fide Food and Drug Administration–approved …

The world is totally dependent on medications. As science progresses, new, better, and
cheaper drugs are needed more than ever. The pharmaceutical industry has been …

Bromodomain testis (BRDT), a member of the bromodomain and extraterminal (BET)
subfamily that includes the cancer targets BRD2, BRD3, and BRD4, is a validated …

The application of peptide drugs in cancer therapy is impeded by their poor biostability and
weak cell permeability. Therefore, it is imperative to find biostable and cell-permeable …

An ideal DNA‐encoded library (DEL) selection requires the library to consist of diverse core
skeletons and cover chemical space as much as possible. However, the lack of efficient on …

BACKGROUND The high rates of unintended pregnancy and the ever-growing world
population impose health, economic, social, and environmental threats to countries …

The development of SARS-CoV-2 main protease (Mpro) inhibitors for the treatment of
COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of …