Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria

CW Hall, TF Mah - FEMS microbiology reviews, 2017 - academic.oup.com
Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix
that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic …

Biofilm infections, their resilience to therapy and innovative treatment strategies

U Römling, C Balsalobre - Journal of internal medicine, 2012 - Wiley Online Library
Biofilm formation of microorganisms causes persistent tissue and foreign body infections
resistant to treatment with antimicrobial agents. Up to 80% of human bacterial infections are …

Critical aspects of using bacterial cell viability assays with the fluorophores SYTO9 and propidium iodide

P Stiefel, S Schmidt-Emrich, K Maniura-Weber, Q Ren - BMC microbiology, 2015 - Springer
Background Viability staining with SYTO9 and propidium iodide (PI) is a frequently used tool
in microbiological studies. However, data generated by such routinely used method are …

[HTML][HTML] Antimicrobial susceptibility testing in biofilm-growing bacteria

MD Macia, E Rojo-Molinero, A Oliver - Clinical Microbiology and Infection, 2014 - Elsevier
Biofilms are organized bacterial communities embedded in an extracellular polymeric matrix
attached to living or abiotic surfaces. The development of biofilms is currently recognized as …

Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

S Wagner, R Sommer, S Hinsberger, C Lu… - Journal of medicinal …, 2016 - ACS Publications
Infections with Pseudomonas aeruginosa have become a concerning threat in hospital-
acquired infections and for cystic fibrosis patients. The major problem leading to high …

Prevalence and Characterization of Staphylococcus aureus Cultured From Raw Milk Taken From Dairy Cows With Mastitis in Beijing, China

W Wang, X Lin, T Jiang, Z Peng, J Xu, L Yi… - Frontiers in …, 2018 - frontiersin.org
The colonization of dairy herds and subsequent contamination of raw milk by
Staphylococcus aureus (S. aureus), especially those expressing a multi-drug resistance …

The Pseudomonas aeruginosa Transcriptome in Planktonic Cultures and Static Biofilms Using RNA Sequencing

A Dötsch, D Eckweiler, M Schniederjans… - PloS one, 2012 - journals.plos.org
In this study, we evaluated how gene expression differs in mature Pseudomonas aeruginosa
biofilms as opposed to planktonic cells by the use of RNA sequencing technology that gives …

Ultrasound‐enhanced antibacterial activity of polymeric nanoparticles for eradicating bacterial biofilms

S Gopalakrishnan, A Gupta… - Advanced …, 2022 - Wiley Online Library
Bacterial biofilms are a major healthcare concern resulting in refractory conditions such as
chronic wounds, implant infections and failure, and multidrug‐resistant infections …

Multidrug-resistant Neisseria gonorrhoeae infection in heterosexual men with reduced susceptibility to ceftriaxone, first report in Thailand

N Kueakulpattana, DL Wannigama, S Luk-In… - Scientific Reports, 2021 - nature.com
The global rapid emergence of azithromycin/ceftriaxone resistant Neisseria gonorrhoeae
threatens current recommend azithromycin/ceftriaxone dual therapy for gonorrhea to ensure …

Novel colistin-EDTA combination for successful eradication of colistin-resistant Klebsiella pneumoniae catheter-related biofilm infections

AMS Shein, DL Wannigama, PG Higgins, C Hurst… - Scientific reports, 2021 - nature.com
Abstract Development of an effective therapy to overcome colistin resistance in Klebsiella
pneumoniae, a common pathogen causing catheter-related biofilm infections in vascular …