Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …

Chronic lower airway infection with Pseudomonas aeruginosa is a major contributor to
morbidity and mortality in individuals suffering from the genetic disease cystic fibrosis (CF) …

Laboratory models are critical to basic and translational microbiology research. Models
serve multiple purposes, from providing tractable systems to study cell biology to allowing …

Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated
with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P …

Pseudomonas aeruginosa and Staphylococcus aureus are the two most prevalent bacteria
species in the lungs of cystic fibrosis (CF) patients and are associated with poor clinical …

Pseudomonas aeruginosa is one of the main microbial species colonizing the lungs of cystic
fibrosis patients and is responsible for the decline in respiratory function. Despite the hostile …

Highlights•Some persistent infections are linked to drug resistance and adverse outcomes
such as cancer.•Longitudinal human-infection studies offer access to early and late infection …

Ciprofloxacin (CIP) is used to treat Pseudomonas aeruginosa biofilm infections. We showed
that the pathways of CIP-resistance development during exposure of biofilms and planktonic …

Within-host adaptation is a hallmark of chronic bacterial infections, involving substantial
genomic changes. Recent large-scale genomic data from prolonged infections allow the …

Evolution by natural selection under complex and dynamic environmental conditions occurs
through intricate and often counterintuitive trajectories affecting many genes and metabolic …