The human body generates 10–100 billion cells every day, and the same number of cells
die to maintain homeostasis in our body. Cells infected by bacteria or viruses also die. The …

The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …

Calcium-activated chloride channels (CaCCs) encoded by TMEM16A,, control neuronal
signalling, smooth muscle contraction, airway and exocrine gland secretion, and rhythmic …

The calcium-activated chloride channel TMEM16A is a ligand-gated anion channel that
opens in response to an increase in intracellular Ca2+ concentration,,. The protein is …

The TMEM16 family of proteins, also known as anoctamins, features a remarkable functional
diversity. This family contains the long sought-after Ca2+-activated chloride channels as well …

The lipid scramblase TMEM16F initiates blood coagulation by catalyzing the exposure of
phosphatidylserine in platelets. The protein is part of a family of membrane proteins, which …

Abstract Ca 2+-activated Cl− channels (CaCCs) are a class of Cl− channels activated by
intracellular Ca 2+ that are known to mediate numerous physiological functions. In 2008, the …

Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated
bidirectional transport of phospholipids down their concentration gradient between …

The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

Anoctamin (ANO)/TMEM16 proteins exhibit diverse functions in cells throughout the body
and are implicated in several human diseases. Although the founding members ANO1 …