The ProTide Prodrug Technology: From the Concept to the Clinic: Miniperspective
Y Mehellou, HS Rattan, J Balzarini - Journal of medicinal …, 2017 - ACS Publications
The ProTide technology is a prodrug approach developed for the efficient intracellular
delivery of nucleoside analogue monophosphates and monophosphonates. In this …
delivery of nucleoside analogue monophosphates and monophosphonates. In this …
Current concepts for genital herpes simplex virus infection: diagnostics and pathogenesis of genital tract shedding
C Johnston, L Corey - Clinical microbiology reviews, 2016 - Am Soc Microbiol
SUMMARY Herpes simplex virus 2 (HSV-2) is a DNA virus that is efficiently transmitted
through intimate genital tract contact and causes persistent infection that cannot be …
through intimate genital tract contact and causes persistent infection that cannot be …
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2
C Celum, A Wald, JR Lingappa… - New England journal …, 2010 - Mass Medical Soc
Background Most persons who are infected with human immunodeficiency virus type 1 (HIV-
1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated …
1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated …
Valganciclovir Reduces T Cell Activation in HIV-Infected Individuals With Incomplete CD4+ T Cell Recovery on Antiretroviral Therapy
Background. Elevated immune activation persists during treated human immunodeficiency
virus (HIV) infection and is associated with blunted CD4 recovery and premature mortality …
virus (HIV) infection and is associated with blunted CD4 recovery and premature mortality …
Herpes simplex keratitis: challenges in diagnosis and clinical management
TN Azher, XT Yin, D Tajfirouz, AJW Huang… - Clinical …, 2017 - Taylor & Francis
Herpes simplex virus is responsible for numerous ocular diseases, the most common of
which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically …
which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically …
A systematic approach to virus–virus interactions
T DaPalma, BP Doonan, NM Trager, LM Kasman - Virus research, 2010 - Elsevier
A virus–virus interaction is a measurable difference in the course of infection of one virus as
a result of a concurrent or prior infection by a different species or strain of virus. Many such …
a result of a concurrent or prior infection by a different species or strain of virus. Many such …
Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis
Background Paediatric multidrug-resistant (MDR) tuberculosis is a public health challenge
of growing concern, accounting for an estimated 15% of all global cases of MDR …
of growing concern, accounting for an estimated 15% of all global cases of MDR …
Phosphoramidates and phosphonamidates (ProTides) with antiviral activity
M Slusarczyk, M Serpi… - Antiviral Chemistry and …, 2018 - journals.sagepub.com
Following the first report on the nucleoside phosphoramidate (ProTide) prodrug approach in
1990 by Chris McGuigan, the extensive investigation of ProTide technology has begun in …
1990 by Chris McGuigan, the extensive investigation of ProTide technology has begun in …
HIV nucleoside reverse transcriptase inhibitors
More than 40 years into the pandemic, HIV remains a global burden and as of now, there is
no cure in sight. Fortunately, highly active antiretroviral therapy (HAART) has been …
no cure in sight. Fortunately, highly active antiretroviral therapy (HAART) has been …
Treatment to prevent transmission of HIV-1
MS Cohen, CL Gay - Clinical infectious diseases, 2010 - academic.oup.com
Antiretroviral therapy (ART) has the potential to prevent human immunodeficiency virus
(HIV) transmission by reducing the concentration of HIV in blood and genital secretions …
(HIV) transmission by reducing the concentration of HIV in blood and genital secretions …