Acute kidney injury (AKI) is defined as a rapid decline in renal function and is characterized
by excessive renal inflammation and programmed death of resident cells. AKI shows high …

Over a decade ago, it was proposed that the regulation of tubular repair in the kidney might
involve the recapitulation of developmental pathways. Although the kidney cannot generate …

Reductions in vascular density occur following acute ischemia-reperfusion (I/R) injury that
may predispose the development of chronic kidney disease. The mechanisms mediating …

Transforming growth factor-β (TGFβ) is a key mediator of fibroblast activation in fibrotic
diseases, including systemic sclerosis. Here we show that Engrailed 1 (EN1) is reexpressed …

CKD (chronic kidney disease) has become a public health problem. The therapeutic
approaches have been able to reduce proteinuria, but have not been successful in limiting …

Damage to peritubular capillaries is a key process that contributes to acute kidney injury
(AKI) progression. Vascular endothelial growth factor A (VEGFA) plays a critical role in …

The aim of our work was to evaluate, in an animal model of severe diabetes mellitus, the
effect of mesenchymal stem cells (MSCs) administration on diabetic nephropathy (DN) …

Importance of the field: Good organ preservation is a determinant of graft outcome after
revascularization. The necessity of increasing the quality of organ preservation, as well as of …

Therapeutic approaches for CKD (chronic kidney disease) have been able to reduce
proteinuria, but not diminish the disease progression. We have demonstrated beneficial …

Abstract Fibroblast growth factor 2 (FGF2) consists of multiple protein isoforms (low
molecular weight, LMW, and high molecular weight, HMW) produced by alternative …