Phospholipid remodeling in physiology and disease
B Wang, P Tontonoz - Annual review of physiology, 2019 - annualreviews.org
Phospholipids are major constituents of biological membranes. The fatty acyl chain
composition of phospholipids determines the biophysical properties of membranes and …
composition of phospholipids determines the biophysical properties of membranes and …
Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation
LH Boudreau, AC Duchez, N Cloutier… - Blood, The Journal …, 2014 - ashpublications.org
Mitochondrial DNA (mtDNA) is a highly potent inflammatory trigger and is reportedly found
outside the cells in blood in various pathologies. Platelets are abundant in blood where they …
outside the cells in blood in various pathologies. Platelets are abundant in blood where they …
Phospholipase A2 structure/function, mechanism, and signaling1
JE Burke, EA Dennis - Journal of lipid research, 2009 - ASBMB
Tremendous advances in understanding the structure and function of the superfamily of
phospholipase A 2 (PLA 2) enzymes has occurred in the twenty-first century. The …
phospholipase A 2 (PLA 2) enzymes has occurred in the twenty-first century. The …
The expanding superfamily of phospholipase A2 enzymes: classification and characterization
DA Six, EA Dennis - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2000 - Elsevier
The phospholipase A2 (PLA2) superfamily consists of a broad range of enzymes defined by
their ability to catalyze the hydrolysis of the middle (sn-2) ester bond of substrate …
their ability to catalyze the hydrolysis of the middle (sn-2) ester bond of substrate …
Recent progress in phospholipase A2 research: from cells to animals to humans
M Murakami, Y Taketomi, Y Miki, H Sato… - Progress in lipid …, 2011 - Elsevier
Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …
related enzymes, which are subdivided into several classes including low-molecular-weight …
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP
JD Clark, LL Lin, RW Kriz, CS Ramesha, LA Sultzman… - Cell, 1991 - cell.com
We report the cloning and expression of a cDNA encoding a high molecular weight (85.2 kd)
cytosolic phospholipase Az (cPLA2) that has no detectable sequence homology with the …
cytosolic phospholipase Az (cPLA2) that has no detectable sequence homology with the …
Phospholipase A2
M Murakami, I Kudo - The journal of biochemistry, 2002 - academic.oup.com
Phospholipase A2 (PLA2 catalyzes the hydrolysis of the sn-2 position of membrans
glyerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …
glyerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …
Phospholipase A2 enzymes
I Kudo, M Murakami - Prostaglandins & other lipid mediators, 2002 - Elsevier
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …
A new era of secreted phospholipase A2
M Murakami, H Sato, Y Miki, K Yamamoto… - Journal of lipid …, 2015 - ASBMB
Among more than 30 members of the phospholipase A 2 (PLA 2) superfamily, secreted PLA
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …