Since the first polygenic risk score (PRS) in 2007, research in this area has progressed
significantly. The increasing number of SNPs that have been identified by large scale GWAS …

Genotype‐guided warfarin dosing algorithms are a rational approach to optimize warfarin
dosing and potentially reduce adverse drug events. Diverse populations, such as African …

The development of new knowledge around the genetic determinants of variable drug action
has naturally raised the question of how this new knowledge can be used to improve the …

Introduction Racial and ethnic categories are frequently used in pharmacogenetics literature
to stratify patients; however, these categories can be inconsistent across different studies. To …

Background: There is increasing concern for the potential impact of health care algorithms
on racial and ethnic disparities. Purpose: To examine the evidence on how health care …

Warfarin is the most commonly used oral anticoagulant in sub‐Saharan Africa. Dosing is
challenging due to a narrow therapeutic index and high interindividual variability in dose …

Many practitioners who have not had pharmacogenomic education are required to apply
pharmacogenomics to their practices. Although many aspects of pharmacogenomics are …

Objective We assessed the influence of age on warfarin dose, percentage time in target
range (PTTR), and risk of major hemorrhage. Design Warfarin users recruited into a large …

Pharmacogenomic (PGx) testing is gaining recognition from physicians, pharmacists and
patients as a tool for evidence-based medication management. However, seemingly similar …

Abstract Background Pharmacogenomics (PGx) examines the influence of genetic variation
on drug responses. With more and more Clinical Pharmacogenetics Implementation …