Risk Factors for Recurrence, Complications and Mortality in Clostridium difficile Infection: A Systematic Review

CN Abou Chakra, J Pepin, S Sirard, L Valiquette - PloS one, 2014 - journals.plos.org
Background Clostridium difficile infection (CDI) can lead to complications, recurrence, and
death. Numerous studies have assessed risk factors for these unfavourable outcomes, but …

Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis

A Deshpande, V Pasupuleti, P Thota, C Pant… - infection control & …, 2015 - cambridge.org
OBJECTIVEAn estimated 20–30% of patients with primary Clostridium difficile infection
(CDI) develop recurrent CDI (rCDI) within 2 weeks of completion of therapy. While the actual …

Treatment failure and recurrence of Clostridium difficile infection following treatment with vancomycin or metronidazole: a systematic review of the evidence

KZ Vardakas, KA Polyzos, K Patouni… - International journal of …, 2012 - Elsevier
The objective of this review was to evaluate the frequency of treatment failure and
recurrence of Clostridium difficile infection (CDI) following treatment with vancomycin or …

Consequences of Clostridium difficile infection: understanding the healthcare burden

E Bouza - Clinical microbiology and infection, 2012 - Wiley Online Library
C lostridium difficile is the leading cause of infectious nosocomial diarrhoea in developed
countries, with a measured incidence of approximately five episodes per 10 000 days of …

Evaluation of bacteriophage therapy to control Clostridium difficile and toxin production in an in vitro human colon model system

E Meader, MJ Mayer, D Steverding, SR Carding… - Anaerobe, 2013 - Elsevier
Clostridium difficile is a leading cause of hospital-acquired diarrhoea and represents a
major challenge for healthcare providers. Due to the decreasing efficacy and associated …

Subinhibitory concentrations of metronidazole increase biofilm formation in Clostridium difficile strains

C Vuotto, I Moura, F Barbanti, G Donelli… - FEMS Pathogens and …, 2016 - academic.oup.com
Resistance mechanism to metronidazole is still poorly understood, even if the number of
reports on Clostridium difficile strains with reduced susceptibility to this antibiotic is …

Auranofin, at clinically achievable dose, protects mice and prevents recurrence from Clostridioides difficile infection

NS Abutaleb, MN Seleem - Scientific reports, 2020 - nature.com
Clostridioides difficile is the leading cause of nosocomial infections and a worldwide urgent
public health threat. Without doubt, there is an urgent need for new effective anticlostridial …

[HTML][HTML] Risk factors of Clostridium difficile-associated diarrhea in hospitalized adults: Vary by hospitalized duration

YP Hung, JC Lee, BY Tsai, JL Wu, HC Liu… - Journal of Microbiology …, 2021 - Elsevier
Background Clostridium difficile is the leading cause of nosocomial infectious diarrhea.
Hospitalized patients were at risk of C. difficile-associated diarrhea (CDAD). However the …

The Association between Histamine 2 Receptor Antagonist Use and Clostridium difficile Infection: A Systematic Review and Meta-analysis

IM Tleyjeh, AAB Abdulhak, M Riaz, MA Garbati… - PLoS …, 2013 - journals.plos.org
Background Clostridium difficile infection (CDI) is a major health problem. Epidemiological
evidence suggests that there is an association between acid suppression therapy and …

Factors predicting recurrence of Clostridium difficile infection (CDI) in hospitalized patients: retrospective study of more than 2000 patients

M Abdelfatah, R Nayfe, A Nijim… - Journal of …, 2015 - journals.sagepub.com
Background Clostridium difficile infection (CDI) has increased in incidence and severity
worldwide, causing direct costs estimated to range from US 3.2billionto 4.8 billion. The aim …