[HTML][HTML] Studying human neurological disorders using induced pluripotent stem cells: from 2D monolayer to 3D organoid and blood brain barrier models

S Logan, T Arzua, SG Canfield… - Comprehensive …, 2019 - ncbi.nlm.nih.gov
Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

How to reprogram human fibroblasts to neurons

Z Xu, S Su, S Zhou, W Yang, X Deng, Y Sun, L Li, Y Li - Cell & Bioscience, 2020 - Springer
Destruction and death of neurons can lead to neurodegenerative diseases. One possible
way to treat neurodegenerative diseases and damage of the nervous system is replacing …

Using patient-derived induced pluripotent stem cells to identify Parkinson's disease-relevant phenotypes

SL Sison, SC Vermilyea, ME Emborg… - Current neurology and …, 2018 - Springer
Abstract Purpose of Review Parkinson's disease (PD) is the second most common
neurodegenerative disorder affecting older individuals. The specific cause underlying …

Stem cells for modeling and therapy of Parkinson's disease

Q Zhang, W Chen, S Tan, T Lin - Human gene therapy, 2017 - liebertpub.com
Parkinson's disease (PD) is the second most frequent neurodegenerative disease after
Alzheimer's disease, which is characterized by a low level of dopamine being expressing in …

Novel tools towards magnetic guidance of neurite growth:(I) Guidance of magnetic nanoparticles into neurite extensions of induced human neurons and in vitro …

H Schöneborn, F Raudzus, E Secret, N Otten… - Journal of Functional …, 2019 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease associated with loss or
dysfunction of dopaminergic neurons located in the substantia nigra (SN), and there is no …

[HTML][HTML] Induced dopaminergic neurons: A new promise for Parkinson's disease

Z Xu, X Chu, H Jiang, H Schilling, S Chen, J Feng - Redox Biology, 2017 - Elsevier
Motor symptoms that define Parkinson's disease (PD) are caused by the selective loss of
nigral dopaminergic (DA) neurons. Cell replacement therapy for PD has been focused on …

Combination of epigenetic erasing and mechanical cues to generate human epiBlastoids from adult dermal fibroblasts

G Pennarossa, S Arcuri, T De Iorio, S Ledda… - Journal of Assisted …, 2023 - Springer
Purpose This study is to develop a new protocol that combines the use of epigenetic cues
and mechanical stimuli to assemble 3D spherical structures, arbitrarily defined …

Transcription factors: Time to deliver

AV Ulasov, AA Rosenkranz, AS Sobolev - Journal of Controlled Release, 2018 - Elsevier
Transcription factors (TFs) are at the center of the broad regulatory network orchestrating
gene expression programs that elicit different biological responses. For a long time, TFs …

Current approaches and molecular mechanisms for directly reprogramming fibroblasts into neurons and dopamine neurons

F Han, Y Liu, J Huang, X Zhang, C Wei - Frontiers in Aging …, 2021 - frontiersin.org
Parkinson's disease is mainly caused by specific degeneration of dopaminergic neurons
(DA neurons) in the substantia nigra of the middle brain. Over the past two decades …

Reprogramming of somatic cells to induced neural stem cells

E Shahbazi, F Mirakhori, V Ezzatizadeh, H Baharvand - Methods, 2018 - Elsevier
Recent investigations have demonstrated that defined sets of exogenous factors (chemical
and/or biochemical) can convert human and mouse somatic cells into induced neural stem …