Inflammation: the incubator of the tumor microenvironment

D Denk, FR Greten - Trends in Cancer, 2022 - cell.com
An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

Tumor-associated macrophages: recent insights and therapies

J Zhou, Z Tang, S Gao, C Li, Y Feng, X Zhou - Frontiers in oncology, 2020 - frontiersin.org
Macrophages, which have functions of engulfing and digesting foreign substances, can
clear away harmful matter, including cellular debris and tumor cells. Based on the condition …

Exploiting innate immunity for cancer immunotherapy

M Yi, T Li, M Niu, Q Mei, B Zhao, Q Chu, Z Dai, K Wu - Molecular cancer, 2023 - Springer
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Role of STAT3 signaling pathway in breast cancer

J Ma, L Qin, X Li - Cell Communication and Signaling, 2020 - Springer
Breast cancer has grown to be the second leading cause of cancer-related deaths in
women. Only a few treatment options are available for breast cancer due to the widespread …

Cancer stemness meets immunity: from mechanism to therapy

P Chen, WH Hsu, J Han, Y Xia, RA DePinho - Cell reports, 2021 - cell.com
Cancer stem cells (CSCs) are self-renewing cells that facilitate tumor initiation, promote
metastasis, and enhance cancer therapy resistance. Transcriptomic analyses across many …

Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

Y Xiong, Y Rao, J Hu, Z Luo, C Chen - Advanced materials, 2023 - Wiley Online Library
Rapid advancements in materials science and nanotechnology, intertwined with oncology,
have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy …

Mechanisms of macrophage plasticity in the tumor environment: manipulating activation state to improve outcomes

TD Ricketts, N Prieto-Dominguez, PS Gowda… - Frontiers in …, 2021 - frontiersin.org
Macrophages are a specialized class of innate immune cells with multifaceted roles in
modulation of the inflammatory response, homeostasis, and wound healing. While …

STAT family of transcription factors in breast cancer: Pathogenesis and therapeutic opportunities and challenges

GL Wong, SG Manore, DL Doheny, HW Lo - Seminars in cancer biology, 2022 - Elsevier
Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …

Decoding the spatiotemporal heterogeneity of tumor-associated macrophages

X Chu, Y Tian, C Lv - Molecular Cancer, 2024 - Springer
Tumor-associated macrophages (TAMs) are pivotal in cancer progression, influencing tumor
growth, angiogenesis, and immune evasion. This review explores the spatial and temporal …

Tumor purity as a prognosis and immunotherapy relevant feature in gastric cancer

Z Gong, J Zhang, W Guo - Cancer medicine, 2020 - Wiley Online Library
Tumor microenvironment (TME) has been illustrated their clinic pathological significance in
predicting outcomes and therapeutic efficacy by more and more studies. Tumor purity, which …