Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …

ACE 2, a novel homologue of angiotensin converting enzyme, has recently been identified.
This study used QRT-PCR to quantitatively map the transcriptional expression profile of ACE …

Angiotensin II (Ang II) has been implicated in the development of progressive
glomerulosclerosis, but the precise mechanism of this effect remains unclear. In an …

The renin-angiotensin system is a major regulatory system of cardiovascular and renal
function. Basic research has revealed exciting new aspects, which could lead to novel or …

There is mounting evidence to support the influence of inflammation in the pathogenesis of
atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory …

Diabetes mellitus is characterized by a lack of insulin causing elevated blood glucose, often
with associated insulin resistance. Over time, especially in genetically susceptible …

Angiotensin II (ANG II) is known to be a potent growth promoting factor for vascular smooth
muscle cells and fibroblasts but little is known about its influence on growth in endothelial …

Angiotensin II regulates blood pressure and may affect adipogenesis and adipocyte
metabolism. Angiotensin II is produced by cleavage of angiotensinogen by renin and …

AIMS/BACKGROUND: All components necessary for the formation of angiotensin II, the
biologically active product of the renin-angiotensin system (RAS), have been demonstrated …