Recent understanding of soil acidobacteria and their ecological significance: a critical review

S Kalam, A Basu, I Ahmad, RZ Sayyed… - Frontiers in …, 2020 - frontiersin.org
Acidobacteria represents an underrepresented soil bacterial phylum whose members are
pervasive and copiously distributed across nearly all ecosystems. Acidobacterial sequences …

Advances and challenges in metatranscriptomic analysis

M Shakya, CC Lo, PSG Chain - Frontiers in genetics, 2019 - frontiersin.org
Sequencing-based analyses of microbiomes have traditionally focused on addressing the
question of community membership and profiling taxonomic abundance through amplicon …

Personalized mapping of drug metabolism by the human gut microbiome

B Javdan, JG Lopez, P Chankhamjon, YCJ Lee, R Hull… - Cell, 2020 - cell.com
The human gut microbiome harbors hundreds of bacterial species with diverse biochemical
capabilities. Dozens of drugs have been shown to be metabolized by single isolates from …

Next-generation approaches to understand and combat the antibiotic resistome

TS Crofts, AJ Gasparrini, G Dantas - Nature Reviews Microbiology, 2017 - nature.com
Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …

Linking soils to ecosystem services—A global review

K Adhikari, AE Hartemink - Geoderma, 2016 - Elsevier
Soil plays a crucial role in ecosystem functioning. In the 1990s ecosystem services (ES)
research focused on developing the concept and framework and only a few studies linked …

Advances in ultrahigh-throughput screening for directed enzyme evolution

U Markel, KD Essani, V Besirlioglu, J Schiffels… - Chemical Society …, 2020 - pubs.rsc.org
Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …

Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis

A Crits-Christoph, S Diamond, CN Butterfield… - Nature, 2018 - nature.com
In soil ecosystems, microorganisms produce diverse secondary metabolites such as
antibiotics, antifungals and siderophores that mediate communication, competition and …

Soil health assessment: A critical review of current methodologies and a proposed new approach

O Rinot, GJ Levy, Y Steinberger, T Svoray… - Science of the Total …, 2019 - Elsevier
The wellbeing of soils is crucial for securing food production worldwide. The soil health (SH)
concept has been introduced due to an evolving understanding that soil is not just a growing …

Sequencing and beyond: integrating molecular'omics' for microbial community profiling

EA Franzosa, T Hsu, A Sirota-Madi… - Nature Reviews …, 2015 - nature.com
High-throughput DNA sequencing has proven invaluable for investigating diverse
environmental and host-associated microbial communities. In this Review, we discuss …

Natural products: a continuing source of novel drug leads

GM Cragg, DJ Newman - Biochimica et Biophysica Acta (BBA)-General …, 2013 - Elsevier
BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …