Sepsis remains a major cause of morbidity and mortality worldwide, with increased burden
in low-and middle-resource settings. The role of the inflammatory response in the …

Since the definition of systemic inflammatory response syndrome/sepsis was originally
proposed, a large amount of new information has been generated showing a much more …

Background & Aims Characteristics of decompensated cirrhosis and acute-on-chronic liver
failure (ACLF) include susceptibility to infection, immuneparesis, and monocyte dysfunction …

Severe septic syndromes deeply impair innate and adaptive immunity and are responsible
for sepsis-induced immunosuppression. Although neutrophils represent the first line of …

Systemic inflammation results in release of refractory neutrophils which can cause
susceptibility to infections and activates differentiated neutrophils, which can mediate tissue …

Severe sepsis and organ failure are still the major causes of postoperative morbidity and
mortality after major hepatobiliary pancreatic surgery. Despite recent progress in …

Toll-like receptor 4 (TLR4), together with MD-2, binds bacterial endotoxins (E) with high
affinity, triggering formation of the activated homodimer (E. MD-2. TLR4) 2. Activated TLR4 …

Rationale: Population studies suggest improved sepsis outcomes with statins, but the results
of randomized controlled trials in patients with sepsis and organ dysfunction in critical care …

The pathogenesis of sepsis involves complex interaction between the host and the infecting
microorganism. Bacterial recognition and signaling are essential functions of the cells of …

While single cell RNA sequencing (scRNA-seq) is invaluable for studying cell populations,
cell-surface proteins are often integral markers of cellular function and serve as primary …