Oxygen, which is necessary for sustaining energy metabolism, is consumed in many
biochemical reactions in eukaryotes. When the oxygen supply is insufficient for maintaining …

Various wounds caused by burns, trauma, surgery, and genetic irregularities, including
acute and chronic wounds, pose a huge burden on global healthcare. Many therapeutic …

Abstract Background Long non-coding RNAs (lncRNAs) are widely involved in human
cancers' progression by regulating tumor cells' various malignant behaviors. MAPKAPK5 …

Abstract Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic
mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine …

Three-dimensional image analyses are required to improve the understanding of the
regulation of blood vessel formation and heterogeneity. Currently, quantitation of 3D …

The treatment of complex or chronic skin wounds caused by burns, trauma, surgery, and
genetic disorders has been a worldwide challenge. Small intestinal submucosa (SIS) is a …

Gestational diabetes mellitus (GDM) has become a major public health problem and one of
the most discussed issues in modern obstetrics. GDM is associated with serious adverse …

Background: The kidney requires abundant blood supply, and oxygen is transmitted by
diffusion through blood vessels. Most physiological metabolism of the kidney depends on …

Minerals play a vital role, working synergistically with enzymes and other cofactors to
regulate physiological functions including tissue healing and regeneration. The bioactive …

Hypoxia is a common denominator in the pathophysiology of a variety of human disease
states. Insight into how cells detect, and respond to low oxygen is crucial to understanding …