Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Axons in the peripheral nervous system have the ability to repair themselves after damage,
whereas axons in the central nervous system are unable to do so. A common and important …

Neuronal models are a crucial tool in neuroscientific research, helping to elucidate the
molecular and cellular processes involved in disorders of the nervous system. Adapting …

Axon regeneration in the central nervous system normally fails, in part because of a
developmental decline in the intrinsic ability of CNS projection neurons to extend axons …

Target-based high-throughput screening (HTS) has recently been critiqued for its relatively
poor yield compared to phenotypic screening approaches. One type of phenotypic …

Multidomain peptide (MDP) hydrogels are a class of self-assembling materials that have
been shown to elicit beneficial responses for soft tissue regeneration. However, their …

Understanding axon regenerative failure remains a major goal in neuroscience, and
reversing this failure remains a major goal for clinical neurology. Although an inhibitory …

Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during
development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs …

Abstract Automated microscope based High Content Screening (HCS, or HCA, HCI) has
gained significant momentum recently due to its ability to study many features …

Background Automatic quantification of neuronal morphology from images of fluorescence
microscopy plays an increasingly important role in high-content screenings. However, there …