Mitochondria are highly dynamic organelles that participate in ATP generation and involve
calcium homeostasis, oxidative stress response, and apoptosis. Dysfunctional or damaged …

Cell survival, tissue integrity and organismal health depend on the ability to maintain
functional protein networks even under conditions that threaten protein integrity. Protection …

Restrictive cardiomyopathy is a rare cardiac disease causing severe diastolic dysfunction,
ventricular stiffness and dilated atria. In consequence, it induces heart failure often with …

Restrictive cardiomyopathy (RCM), a potentially devastating heart muscle disorder, is
characterized by diastolic dysfunction due to abnormal muscle relaxation and myocardial …

Oxidative stress-associated endothelial damage is the initiation factor of cardiovascular
disease, and protein posttranslational modifications play critical roles in this process. Bcl-2 …

Chaperone-assisted selective autophagy (CASA) is a highly selective pathway for the
disposal of misfolding and aggregating proteins. In muscle, CASA assures muscle integrity …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Proteome maintenance in contracting skeletal and cardiac muscles depends on the
chaperone-regulating protein BAG3. Reduced BAG3 activity leads to muscle weakness and …

Cardiomyopathy is a prevalent cardiovascular disease that affects individuals of all ages
and can lead to life-threatening heart failure. Despite its variety in types, each with distinct …

B-cell lymphoma 2–associated athanogene-3 (Bag3) is expressed in all animal species,
with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous …