Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Evidence from human studies, animal models, and bioengineered arteries supports the
hypothesis that HDL protects against cerebrovascular dysfunction in Alzheimer's disease …

Introduction It is unknown whether vascular and metabolic diseases assessed in early
adulthood are associated with Alzheimer's disease (AD) later in life. Methods Association of …

Alzheimer's disease (AD) affects around 33 million people worldwide, which makes it the
most prominent form of dementia. The main focus of AD research has been on the central …

Cerebrovascular changes occur in Alzheimer's disease (AD). The progesterone receptor
membrane component-1 (PGRMC1) is a well identified hormone receptor with multiple …

Insulin resistance and impaired lipoprotein metabolism contribute to a plethora of metabolic
and cardiovascular disorders. These alterations have been extensively linked with poor …

Background Transcriptome-wide association study (TWAS) is an influential tool for
identifying genes associated with complex diseases whose genetic effects are likely …

Epidemiological studies have shown that low levels of plasma high-density lipoprotein
cholesterol (HDL-C) are associated with increased atherosclerotic cardiovascular disease …

Introduction The neurovascular unit (NVU)–the interaction between the neurons and the
cerebrovasculature–is increasingly important to interrogate through human-based …

Background-HDL inhibits atherosclerosis development from radiation damage, nonetheless,
the underlying mechanism is yet to be defined. Methods-This study used radiation patients …