Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

K Takeuchi, K Reue - American Journal of Physiology …, 2009 - journals.physiology.org
Triacylglycerol (TAG) synthesis and storage in tissues such as adipose tissue and liver have
important roles in metabolic homeostasis. The molecular identification of genes encoding …

Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and …

A Yamashita, Y Hayashi, Y Nemoto-Sasaki, M Ito… - Progress in lipid …, 2014 - Elsevier
Over one hundred different phospholipid molecular species are known to be present in
mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including …

Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling

RA Coleman, DG Mashek - Chemical reviews, 2011 - ACS Publications
Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …

Phosphatidic acid synthesis in bacteria

J Yao, CO Rock - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
Membrane phospholipid synthesis is a vital facet of bacterial physiology. Although the
spectrum of phospholipid headgroup structures produced by bacteria is large, the key …

Transcription corepressor CtBP is an NAD+-regulated dehydrogenase

V Kumar, JE Carlson, KA Ohgi, TA Edwards, DW Rose… - Molecular cell, 2002 - cell.com
Transcriptional repression is based on the selective actions of recruited corepressor
complexes, including those with enzymatic activities. One well-characterized …

Acyltransferases in bacteria

A Röttig, A Steinbüchel - Microbiology and Molecular Biology …, 2013 - Am Soc Microbiol
Long-chain-length hydrophobic acyl residues play a vital role in a multitude of essential
biological structures and processes. They build the inner hydrophobic layers of biological …

How lipid droplets “TAG” along: Glycerolipid synthetic enzymes and lipid storage

H Wang, MV Airola, K Reue - … et Biophysica Acta (BBA)-Molecular and Cell …, 2017 - Elsevier
Triacylglycerols (TAG) serve as the predominant form of energy storage in mammalian cells,
and TAG synthesis influences conditions such as obesity, fatty liver, and insulin resistance …

Glycerophosphate/acylglycerophosphate acyltransferases

A Yamashita, Y Hayashi, N Matsumoto… - Biology, 2014 - mdpi.com
Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-
phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol …

Biosynthesis of γ-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces

J Kato, N Funa, H Watanabe… - Proceedings of the …, 2007 - National Acad Sciences
A factor (2-isocapryloyl-3 R-hydroxymethyl-γ-butyrolactone) is a representative of the γ-
butyrolactone autoregulators that trigger secondary metabolism and morphogenesis in the …

Chloroplast proteomics highlights the subcellular compartmentation of lipid metabolism

J Joyard, M Ferro, C Masselon… - Progress in lipid …, 2010 - Elsevier
Recent advances in the proteomic field have allowed high throughput experiments to be
conducted on chloroplast samples and the data are available in several databases such as …